Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.

Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.

Eur J Pain. 2013 May;17(5):664-75. doi: 10.1002/j.1532-2149.2012.00242.x. Epub 2012 Nov 9.

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1Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
Abstract
BACKGROUND:
β-caryophyllene (BCP) is a common constitute of the essential oils of numerous spice, food plants and major component in Cannabis. The present study investigated the contribution of peripheral cannabinoid (CB) and opioid systems in the antinociception produced by intraplantar (i.pl.) injection of BCP. The interaction between peripheral BCP and morphine was also examined.

http://www.ncbi.nlm.nih.gov/pubmed/23138934






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